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employed protein A domains from various cell surface receptors as the avimer scaffold to generate avimers with a high affinity for type II collagen through in vitro exon shuffling and phage display techniques

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In the basal state PNPLA2 has weak hydrolytic activity which is greatly increased by the co-lipase alpha/beta hydrolase domain-containing protein 5 (ABHD5, also known as CGI-58) by greater than 20-fold (30)