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These results supported that Asp271 and Asp340 play a critical role in lysine recognition during Lys-PG hydrolysis
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in contrast, chronic or constitutive Nrf2 overactivation due to somatic KEAP1/NFE2L2 mutations, epigenetic maladjustment, or persistent pharmacologic stimulation may be used to nourish tumor progression, chemoresistance, metabolic reprogramming and immune-evasive phenotypes in established cancers [15, 393, 394], [83]
