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While agents like DFP and NAC demonstrate favorable BBB penetration, their systemic effects on iron metabolism raise concerns: iron chelators can induce unintended iron deficiency in peripheral tissues, while antioxidants may disrupt physiological redox balance, highlighting the need for brain-targeted delivery to minimize off-target effects
G.McGrawH
It is worth being honest about one thing: B12, as hydroxocobalamin, is a prescription-only medicine in the UK
We then assembled a set of 281 genes that are known to be involved in the response to oxidative stress
