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Low B12 can delay this process a lot
Wang F, Zhang J, Lin X, Yang L, Zhou Q, Mi X, et al
Recently the lipid peroxidation product 4-HNE was shown to directly adduct GCLC Cys553 (and GCLM Cys35) in vitro [132]
When joints are inflamed, they produce excess reactive oxygen species (ROS), which include superoxide and hydrogen peroxide, to the point that they overwhelm the bodys defences and deplete the local glutathione supply [6]
