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The chemical reaction may be expressed as: 1-phosphatidyl-1D- myo -inositol 4,5-bisphosphate + H 2 O 1D- myo -inositol 1,4,5-trisphosphate + diacylglycerol PLCs catalyze the reaction in two sequential steps

However, certain charged and polar species do cross the membrane, aided by proteins that move about in the lipid bilayer

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Experimental study for the establishment of a chemotherapy-induced ovarian insufficiency model in rats by using cyclophosphamide combined with Busulfan