glutathione brain alzheimer's Increasing levels lowers pathology and improves cognitive decline Berberine may benefit Alzheimer's patients

DOI: 10.1016/j.bioactmat.2023.08.008

doi: 10.3389/fimmu.2026.1791087 Received 19 January 2026 Revised 13 March 2026 Accepted 13 March 2026 Published 31 March 2026 Volume 17 - 2026 Edited by Matteo Ripa, Nottingham University Hospitals NHS Trust, United Kingdom Reviewed by Miguel Seabra, Imperial College London, United Kingdom Neetu Kushwah, Boston Childrens Hospital and Harvard Medical School, United States Updates Copyright 2026 Zhu, Lin, Han, Cao, Zhu, Shi, Deng, Li, Yang and Lu

These enzymes constitute the primary cellular defense against reactive oxygen species (ROS), and their expression declines with age in many tissue types

is supported by the UCLA Medical Scientist Training Program (NIH NIGMS training grant GM008042), UCLA Virology and Gene Therapy Training Grant (T32AI060567) and UCLA Tumor Immunology Training Grant (USHHS Ruth L