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In preclinical animal models, atherosclerosis is a progressive disease beginning with the development of fatty streaks and potentially leading to complicated atherosclerotic plaques that can rupture, set up thrombosis and occlude the lumen

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Overall these descriptions match those described by Chapel et al

It appears that certain pathways of carnitine metabolism, such as the acetylation of carnitine to acetyl-carnitine, are impaired, possibly as a result of the toxicity of antiretroviral medication