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Preclinical studies have demonstrated that specific gut microbial populations significantly impact the effectiveness of therapies for chronic infections and immune regulation

244 Using large-scale in vivo CRISPR screening technology, researchers have identified the E3 ligase Cop1 within breast cancer cells as an essential regulator of macrophage chemokine secretion

The damaging effects of Nrf2 modification in the lung, as an example, may increase the susceptibility of the affected tissues to the oxidative stress of the oxygen environment, as well as compromise the function of epithelial cells and phagocytes, such as granulocytic leukocytes and monocytes/macrophages [49,50]