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(Progesterone has the opposite effect in the urinary bladder, raising the threshold of response, but strengthening contraction, as it does in the gallbladder.) Estrogen lowers stimulation threshold in the gallbladder, as it does in the brain

According to the public registry, the trial was completed, and the results suggest a favorable safety profile with no significant adverse events reported (ClinicalTrials.gov Identifier: NCT03416053)