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In addition, interstitial fibrosis accompanied by reduced Leydig-cell density has been reported, suggesting chronic remodelling of testicular tissue

doi: 10.1073/pnas.1113540109 35 ChungK.CoggeshallR

The presence of regulatory elements like ARE, activator protein-1 and NF-kB on GCL heavy subunits promoter enhances its transcription

if secondary antioxidant reserves become saturated, or decline, and primary antioxidant defences are compromised, oxidative stress can become excessive
