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As a method of CRISPR interference (CRISPRi), dCas9 technology can inhibit gene transcription without altering the coding DNA sequence

Biomolecules 10(6):895 Mudassar F, Shen H, ONeill G, Hau E (2020) Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
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demonstrated that the effectiveness of oral glutathione is enhanced when combined with other topical agents, the combined oral and topical use of topical glutathione produced more significant skin-lightening effects as compared to the use of a single agent [14]
