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However, it is highly unlikely that the molecules exported via PGP pumps would reach the nervous system because the pumps are expressed on the apical domain of the intestine and will effectively transport molecules into the intestinal lumen 64

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Microbiome Analyses in Patients with Previously Treated, Deficient DNA Mismatch Repair/Microsatellite Instability-High Metastatic Colorectal Cancer Treated with Nivolumab +/- Ipilimumab: CheckMate 142, Bristol Myers Squibb, 2017

In some patients, gout also manifests as urolithiasis, promoted in part by urine acidity, and increased urine uric acid can promote both uric acid and calcium oxalate urolithiasis