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In terms of pathology, these disorders all show evidence of immune dysfunction, and at the cellular level there is evidence for an impaired mitochondrial function, increased oxidative stress, inflammation, apoptosis/ferroptosis and telomere shortening, as discussed in subsequent sections of this article [15,16]
The Pentose Phosphate Pathway (PPP) is one of the most significant metabolic pathways for NADPH generation
No documented serious adverse events in the available research, though long-term human data is still limited
To this end, we expanded the generic human metabolic reconstruction Recon 2.2 19 by incorporating reactions specific to the substrates essential for the replication of the investigated viruses
