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If NNMT inhibition both restores adipocyte energy expenditure (promoting fat reduction) and supports myogenic differentiation (preserving or enhancing muscle), the net body composition effect could be recomposition simultaneous fat loss and lean mass preservation

The peptide works exclusively through peripheral mechanisms in adipose (fat) tissue rather than through central nervous system pathways that regulate appetite and feeding behavior

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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Ni XP, Butler AA, Cone RD, Humphreys MH