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If you experience worsening fatigue, jaundice (yellowing of skin or eyes), abdominal swelling, or confusion, contact your GP urgently, as these may indicate progression of liver disease requiring medical assessment

For instance, a prolonged consumption of water with increased nitrate levels by dairy cattle is known to impair protein metabolism and glucose utilization

Despite these promising findings, several limitations and challenges remain in current research

A study using a three-dimensional tumour sphere model combined with CRISPR-Cas9 screening reported that Nrf2 overactivation was essential for lung tumour proliferation and survival, whereas silencing of Nrf2 predisposed spherical cells to ferroptosis, which was also consistent with clinical observations [77]