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Description
The process unfolds in a stepwise manner, beginning with the upregulation of cytochrome c (cyt c), followed by the expression of poly ADP polymerase (PARP), which serves as the cleavage substrate of caspase
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Toxicologic, biochemical and histopathologic studies
Consequently, the considerable reactive oxygen species (ROS) formation increased by the electron transport system within the mitochondria under stressful conditions and in aging constitutes a risk for developing AD when no efficient antioxidant system is available
