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4.6 Liver and kidney functions and histopathological findings Approximately 30% of the LZD is excreted unchanged by the kidneys, while the rest is metabolized by oxidizing its morpholine ring, which is facilitated by ROS using NADPH in the liver (Wynalda et al., 2000), resulting in the creation of two metabolites: amino-ethoxy-acetic-acid and hydroxyethyl glycine (Nukui et al., 2013)