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Most importantly, co-administration of nimbolide with metformin or the chemotherapeutic drugs tamoxifen/cisplatin was found to be more efficacious than single agents in abrogating IGF-1/PI3K/Akt/AR signaling suggesting that AKR inhibitors show promise in chemosensitization [199]

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Among these fragments was the tripeptide KPV.

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Nature 535 , 47 (2016)

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Diabetes Care 26 , 17901795 (2003)

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