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Mouse Protocol 2 for Postnatal Manipulation of OXTR/ER Expression The male offspring (6 weeks old) from either the CTL or STZ group in Mouse Protocol 1 were anesthetized with a mixture of ketamine (90 mg/kg) and xylazine (2.7 mg/kg) and implanted with a guide cannula targeting the amygdala (26 gauge

In addition to its role in glucose homeostasis (T2D), and neuroprotective and antioxidant effects, it also shows anti-inflammatory, anti-fungal, anti-bacterial, and antihypertensive effects [5,100]

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Recent studies have also revealed that chronic hyperglycemia results in sustained activation of mTORC1 in cells, leading to increased glucagon secretion 48