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This last version is the only one that has ever been licenced for human use, although its use is now discontinued
Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial

Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma

These C20 and C22 n3-polyunsaturated fatty acids are known to constitute a significant portion of the membrane lipids in critical tissues such as the brain [550], retina [551], and testis [552], reflecting their involvement in neurotransmission, visual excitation, and spermium maturation