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Niacinamide (vitamin B3, technically not peptide but frequently combined in peptide formulations ) addresses pigmented dark circles through multiple mechanisms including inhibiting melanosome transfer from melanocytes to keratinocytes reducing visible pigmentation, anti-inflammatory effects decreasing post-inflammatory hyperpigmentation from rubbing or allergies, and barrier strengthening improving overall skin health and resilience

Pre-clinical work also shows GHK-Cu reducing markers of oxidative stress and inflammatory cytokines in tissue-injury models

[PubMed] [Google Scholar] 45.Trier J.S., Szabo S., Allan C.H

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