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However, no study to date has thoroughly examined how viral proteins simultaneously affect multiple cellular pathways, each controlled by its own feedback mechanisms, and how the disruption of these systems may interact to worsen or prolong disease

254-257 For these reasons, the Panel judged that the risks/burdens of BCG outweigh its benefits for IC/BPS patients in routine clinical care situations

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In serum and plasma, reduced GSH is primarily released by hepatocytes for uptake by the kidney, lung, intestine, and other organs [14]