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Side effects that are noted are usually mild and include momentary irritation at the injection site and fatigue

Nanomaterials (2021) 11(12):3419

When symptoms are attributed to high B12 intake, they typically include: Skin reactions : Acne-like eruptions or rosacea-type rashes, particularly with hydroxocobalamin injections (listed as rare adverse effects in the product information) Gastrointestinal disturbances : Mild nausea, diarrhoea, or abdominal discomfort Headaches : Occasional reports of headache following B12 injections Anxiety or restlessness : Anecdotal reports, though causation remains unestablished It is crucial to distinguish between symptoms caused by elevated B12 levels and those arising from the underlying conditions that elevate B12

All scores were assessed using the semiquantitative H scoring approach by two experienced pathologists who were blinded for the assessment