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The activated AMPK activates the transcriptional factor FOXO3 that affects such processes as cell proliferation, gluconeogenesis, and defense against oxidative stress through the activation of the PI3K/AKT signal pathway [117]

Such effects could offer new hope for preventing or slowing neurodegenerative diseases such as Alzheimers and Parkinsons disease (1)
doi: 10.1016/j.bios.2009.07.038

The model was based as much as possible on parameters from the biochemical literature
