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However, HeLa cells are much more sensitive, with 2.5 nM (per million cells) of doxorubicin resulting in up to 80% GSH depletion for the same exposure time 38
[DOI] [PubMed] [Google Scholar] 144.Ravindran R.D., Sundaresan P., Krishnan T., Vashist P., Maraini G., Saravanan V., Chakravarthy U., Smeeth L., Nitsch D., Young I.S., et al

Thats the actual biological reason cycling exists for certain compounds
