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Melatonin supplementation can also modulate the circadian rhythm by causing an advance or delay, depending on the administration time
Experimental studies have utilized diverse animal models including transgenic mice (APP/PS1, 5FAD), senescence-accelerated mice (SAMP8), and even Drosophila melanogaster to explore these mechanisms
The chronic activation of the type I IFN pathway is a hallmark of SLE and contributes to the dysregulation of immune responses in this disease [132]
