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Perimenopause represents a phase of profound endocrine remodeling, during which rapid and irregular fluctuations in sex hormones, particularly E2 and progesterone, markedly impact brain regions, such as the hippocampus and prefrontal cortex, involved in mood regulation (48)
And while the redness and induration can look alarming, they typically resolve within 24 to 72 hours without intervention
& Hughes, R
& Dice, J
