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Subsequently, infiltrating inflammatory mediators and immune cells can trigger reactive activation of microglia and astrocytes, promoting further inflammatory signaling within the CNS and thereby sustaining a neuroinflammatory microenvironment (Linnerbauer et al., 2020

Future Directions: BPC 157 rapidly increases various genes expression in rat excision skin wound

10.1016/j.biomaterials.2024.122581 128 YanoS.NakatakiE.OhtsukaS.InayamaM.TomimotoH.EdakuniN.et al (2005)

Safety concerns were cited for study termination due to development of metabolic toxicities, indicating that approaches targeting the IGF-1R signaling system that preserve metabolic homeostasis are needed for the development of future anticancer therapeutics
