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Effect of endothelin-1 on astrocytic protein content

The preclinical evidence is robust, consistent, and mechanistically plausible, but the gap between rat sciatic nerve transection models and human diabetic neuropathy is significant
PMID: 148 HeJChanTHongXZhengFZhuCYinLet al

Studies have examined its effects on fibroblast activity, extracellular matrix remodeling, antioxidant enzyme expression, and angiogenesis-related signaling pathways
