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Said differently, to significantly advance how we treat bipolar disorder, we will need to replace unidimensional (i.e., purely phenomenological diagnoses) and static (i.e., based on the assumption that the appearance and underlying pathophysiology of the disease do not evolve over time) diagnostic and treatment approaches with strategies that are dynamic and integrated (i.e., including elements such as psychotherapy, pharmacotherapy, exercise, nutrition, meditation, relationship healing, etc.) as well as multi-level (i.e., based on phenomenology, neuroimaging, and biochemical and genetic evaluation)

Sleep improvement is typically the earliest reported benefit of sermorelin therapy and cascades into better daytime energy, mood, and cognitive function

Jia et al

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