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doi: 10.1016/j.molmed.2016.09.003

Present practice is informed by animal studies, off-label veterinary guidelines, and clinical experience, thus treatment must be under veterinary guidance, always

Additionally, higher levels of vascular endothelial growth factor, substance P, and platelet-derived endothelial cell growth factor are often detected in the bladder endothelium of IC patients compared to controls Notably, bladder epithelial cells in individuals with IC exhibit intrinsic alterations in differentiation, neurotransmitter release, potassium channel activity, increased nitric oxide production, nuclear factor-B activation, nerve fiber density, serum C-reactive protein levels, and the production of neuropeptide Y and nerve growth factor

TL;DR There is no single answer