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This impressive array of cellular and molecular functions has piqued considerable interest among the lay public and the research community for the use of LA both as a nutritive supplement and as a pharmacotherapy

These studies suggest that upon MOMP, release of mitochondrial-derived dsRNA can initiate a type I interferon response through dsRNA sensing by RIG-I and MDA5 and subsequent aggregation and activation of MAVS

These receptors contribute to the downregulation of cytokines connected with the IL-23/IL-17 signaling cascade and hinder key molecular pathways like MAPKs and NF-B (48)