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Patients with GATM deficiencies have milder clinical manifestations which are generally limited to moderate intellectual disability and language disorder

detected brain hypometabolism and A deposition in a positron emission tomography (PET) scan of one patient out of 7 patients with cognitive impairment [124], which mandates further investigation

While 12 weeks of bright light exposure did not produce measurable improvements in sleep quality, glucose metabolism, or inflammatory markers, it significantly altered clock gene expression in peripheral blood mononuclear cells (PBMCs, specifically decreasing REV-ERB levels and increasing the REV-ERB/BMAL1 ratio)