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A total sample size of 40 was chosen because it had greater than 80% power to detect a 4-point difference between groups in Montgomery-Asberg Depression Rating Scale (MADRS) scores over 12 weeks, assuming a standard deviation for repeated measures of MADRS of 6, and a within-subject correlation of 0.6

Risk may increase in certain clinical or physiological situations associated with disturbances in transport, balance or carnitine losses, whether due to genetics or other clinical conditions

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These patients experience accumulation of plasma acylcarnitines, in part due to a decreased renal clearance of esterified carnitine moieties [54]
