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Although we failed to detect 5-HT in Mir-NCM, previous report showed that mirtazapine promoted 5-HT release from serotonergic neurons and indirectly stimulates 5-HT1A receptors by blocking 5-HT2 and 5-HT3 receptors 16

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5E), suggesting a dose-dependent protective effect

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All clinical samples used were collected with informed consent from the patients

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