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Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions

The 4-hydroxyestrone pathway is additionally influenced by environmental toxins, so patients who have CYP1B1 SNPs are especially susceptible to estrogen-sensitive cancers

Anti-angiogenic agents, particularly anti-VEGF antibodies (e.g., bevacizumab) and tyrosine kinase inhibitors (e.g., axitinib), have been shown in preclinical models to transiently normalize tumor vasculature and promote T-cell infiltration [201, 202]

Moreover, an increased number of threatening life events has been associated with increased psychosis risk in a dose-response manner 1 year prior to psychosis onset [227]