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Certainly, there seems to be a mismatch between the influence of high UA and that of gout in risk of PD, as mentioned above

However, animal studies have shown systemic effects with oral ingestion and caution is needed

doi: 10.1016/j.micpath.2016.06.008

98 Although berberine has been studied in human clinical trials and shown to have several metabolic benefits, concerns about long-term use of berberine have been raised on the basis of certain preclinical studies
