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You're not alone in this struggle

Elevated daytime DNA oxidative damage (8-OHdG) favors morning dosing, while elevated nighttime inflammatory markers (IL-6, TNF-) support evening protocols

10.1084/jem.20111453 35 ColganS

The clearest visible improvements, measurable changes in skin laxity, firmness, and tone, typically come at the eight to twelve week mark
