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RCT evidence: A: Robust replicated results from at least 2 large long-term double-blind RCT, ideally with confirmation from a systematic review or meta-analysis B: Supporting evidence from the primary outcome of at least one large long-term double-blind RCT C: A lack of supporting evidence from the primary outcome of a large long-term double-blind RCT but promising results from either small pilot RCTs or from post-hoc and planned secondary analyses

A Progenesis QI score 40 was considered to select a candidate for annotation in accordance with reporting criteria for chemical analysis suggested by the Metabolomics Standards Initiative (MSI) 66,67