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These multifaceted effects are attributed to its modulation of key signaling pathways such as Akt, 53 NF-B, 54 mitogen-activated protein kinase (MAPK), and Signal transducer and activator of transcription 3 (STAT3)
These results suggest that TSA, as a phytoestrogen, may have therapeutic potential for cardiovascular diseases in postmenopausal women by activating ERs and the ERK signaling pathway
10.1038/ki.1995.414 2 BanciL.BertiniI.BlaevitO.CalderoneV.CantiniF.MaoJ.et al (2012)

DHA supplementation alone had no effect on any of the above-mentioned parameters
