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Directly Targeting Glutathione Peroxidase 4 May Be More Effective than Disrupting Glutathione on Ferroptosis-Based Cancer Therapy

For instance, in an IL-1-stimulated chondrocyte OA model and a surgically induced OA rat model, exosomes derived from OA patient FLS were found to reduce chondrocyte viability, GSH/GSSG ratio, GPX4, SLC7A11, and MMP levels

TB-500 is a synthetic seven-amino-acid fragment (acetyl-Leu-Lys-Lys-Thr-Glu-Thr-Gln, or Ac-LKKTETQ) corresponding to the actin-binding domain of thymosin beta-4 (T4), a naturally occurring 43-residue peptide present in essentially all human cells

Clinical Significance of Trace Element Zinc in Patients with Chronic Kidney Disease