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It is widely expressed in the CNS (e.g., prefrontal cortex, substantia nigra, raphe nuclei, or hippocampus), PNS, and peripheral tissues (e.g., immune cells), indicating that KORs play an important role in the modulation of pain as well as regulating affective and emotional states [58]

- 2.4 micrograms (mcg) daily for ages 14 years or older - 2.6 mcg daily for pregnant women - 2.8 mcg daily for breastfeeding women For those over 50 years of age, the recommended dietary amount (RDA) is 25 to 100 mcg of B-12 or one can get it by eating vitamin B12-rich foods

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