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The addition of KPV provides enhanced anti-inflammatory effects through different pathways than the other peptides

Because vitamins B12 and folate team up and work with each other and the fact that all other vitamins and minerals are affected by their relationship means that you can have any of the MTHFR symptoms that are the direct result of multiple vitamin and mineral deficiencies that cant be resolved by taking a common multivitamin and mineral supplements

Beijing Methycobal Clinical Trial Collaborative Group]

For most people the cleaner move is simply buying a vial size that fits your protocol, refrigerating it, and using it up skip the whole freeze-thaw problem instead of managing it