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An exemplary case of MRTX849, a covalent inhibitor targeting KRAS G12C mutant, benefited from a lower reactivity warhead with an additional fluorine at the acrylamide -carbon position, thus achieving better metabolic stability [113]
Li B., Zhao M., Lai W., Zhang X., Yang B., Chen X., Ni Q., Angew
What unites these diverse users is a shared frustration: conventional approaches have provided incomplete results, and they are willing to explore research-stage compounds in pursuit of better tissue support and recovery optimization

[DOI] [PubMed] [Google Scholar] 17.Rojas J.C., Bruchey A.K., Gonzalez-Lima F
