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Added value of this study In the current study, we chose to take a different approach by rationally designing a series of peptides to preferentially bind FOXO4 and act as senolytics

Considering the validation of CD38 antibody safety and individual variability in therapeutic efficacy, establishing a rational monitoring strategy is paramount
Journal of Molecular Endocrinology

Cocaine acts as a true competitive inhibitor that directly occupies the S1 central substrate site, physically blocking the reuptake of endogenous monoamines
