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Five- and six-membered nitrogen-containing compounds as selective carbonic anhydrase activators

GSH is exclusively degraded at the extracellular level by cells expressing -glutamyltranspeptidase (GGT), such as those of the hepatobiliary tree and of other organs like the heart, kidney, lungs, pancreas, and seminal vesicles

Patients taking GLM benefited from the therapy by lowering their CRP levels, which translated into significant reductions in other parameters: IL-6, ICAM-1, MMP-3, and VEGF levels [61]

[0122] Embodiment 115: The antibody according to any one of embodiments 1-8, wherein said antibody comprises a heavy chain variable region (VH) of an ALPPL2rd3_2 antibody and a light chain variable region (VL) of an ALPPL2rd3_2 antibody