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This environmental injustice not only perpetuates health disparities but also highlights the urgent need for equitable policies and targeted remediation efforts to protect vulnerable communities from the long-term consequences of Pb exposure

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Moreover, the reaction rate of most antioxidants with ROS is much slower than that of antioxidant enzymes, and their actual antioxidant efficiency in vivo may be lower than expected [29, 30]

The literature reveals that Nrf2 plays a role in the development and progression of gliomas with isocitrate dehydrogenase mutations, further confirming an interplay between oxidative stress and isocitrate dehydrogenase mutations [26]