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repletion reverses hematologic symptoms within days and neurologic sequelae over weeks, reflecting differential tissue turnover

This does not completely negate the peptide, but it reduces efficiency

David Sinclair, a leading voice in longevity research, has stated: NAD+ is the closest we've gotten to a fountain of youth.[2] His research highlights how NAD+ activates pathways that mimic caloric restriction, a known extender of lifespan in models

Li J, et al
