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Hence, more attention should be paid to cancer models without development of cachexia, to rule out all the host adaptions to cancer growth unrelated to cachexia syndrome, and to the different types of cachexia (e.g., cancer cachexia versus septic cachexia) to decipher common and distinct cellular and molecular mechanisms

Busulfan with having two methanesulfonate groups, attached to two ends of a butane chain, hydrolyzes and releases extremely reactive positively charged carbonium ions, which react with the guanine molecules in cell's DNA, resulting in DNA interstrand crosslinks

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