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Knockdown of NCOA4 in HT22 cells rescues KA-mediated down-regulation of FTH1 expression [137]
Additionally, melanocortins such as -melanocyte-stimulating hormone (-MSH), produced by both keratinocytes and melanocytes, activate the melanocortin-1 receptor (MC1R) on melanocytes, further enhancing their antioxidant capacity
E.RushakoffJ
Therefore, it may be feasible to intervene in frailty by modulating oxidative stress
